1,2-Diaryl-1-ethanone and pyrazolo [4,3-c] quinoline-4-one as novel selective cyclooxygenase-2 inhibitors

Bipul Baruah; Kavitha Dasu; Balasubramanian Vaitilingam; Akhila Vanguri; Seshagiri Rao Casturi; Koteswar Rao Yeleswarapu

doi:10.1016/j.bmcl.2003.10.052

1,2-Diaryl-1-ethanone and pyrazolo [4,3-c] quinoline-4-one as novel selective cyclooxygenase-2 inhibitors

Bioorg Med Chem Lett. 2004 Jan 19;14(2):445-8. doi: 10.1016/j.bmcl.2003.10.052.

Authors

Bipul Baruah¹, Kavitha Dasu, Balasubramanian Vaitilingam, Akhila Vanguri, Seshagiri Rao Casturi, Koteswar Rao Yeleswarapu

Affiliation

¹ Inflammation Research Group, Discovery Research, Dr. Reddy's Laboratories Limited, Bollaram Road, Miyapur, -500050, Hyderabad, India.

PMID: 14698178
DOI: 10.1016/j.bmcl.2003.10.052

Abstract

Novel 1,2-diaryl-1-ethanone 1 and pyrazolo [4,3-c] quinoline-4-one 2, with pharmacophores different from the known COX inhibitors were identified as selective COX-2 inhibitors. The communication briefly describes SAR of both the series.

MeSH terms

Cyclooxygenase 1
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors / chemical synthesis*
Cyclooxygenase Inhibitors / metabolism
Isoenzymes / antagonists & inhibitors
Isoenzymes / metabolism
Prostaglandin-Endoperoxide Synthases / metabolism
Quinolines / chemical synthesis*
Quinolines / metabolism

Substances

Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors
Isoenzymes
Quinolines
Cyclooxygenase 1
Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases